7/21/2023 0 Comments Free instals Barbie 2017 Memory![]() ![]() The KLRG1 Hi Teff cell population is often 5-20 times more numerous than the Tmp cell subset and has robust effector functions. These data define a role for TCF-1 in early fate bifurcation driving Tex precursor cells, and also identify PD-1 as a protector of this early TCF-1 subset.ĭuring acute infections or vaccinations, naïve CD8 T cells become activated and differentiate into a pool of effector T cells containing KLRG1 Hi terminal effector (Teff) cells and KLRG1 LoCD127 Hi memory precursors (Tmp) cells ( Kaech and Cui, 2012). TCF-1 mediated a T-bet to Eomes transcription factor transition in Tex precursors by promoting Eomes expression and drove c-Myb expression that controlled Bcl-2 and survival. TCF-1 mediated the bifurcation between divergent fates, repressing development of terminal KLRG1 Hi effectors while fostering KLRG1 Lo Tex precursor cells, and PD-1 stabilized this TCF-1 + Tex precursor cell pool. Single cell RNA-sequencing (scRNA-seq) and lineage tracing identified a TCF-1 +Ly108 +PD-1 + CD8 T cell population early during chronic infection that seeds development of mature Tex cells. However, the role of the transcription factor TCF-1 in early fate decisions and initial generation of Tex cells is unclear. Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. ![]() TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex).
0 Comments
Leave a Reply. |